What do these results mean: ENDOMETRIAL BIOPSY: WEAKLY PROLIFERATIVE ENDOMETRIUM WITH FOCAL STROMAL AND/OR GLANDULAR BREAKDOWN. 1. postmenapausal weakly-proliferative endometrium with focal glandular crowding. Proliferative endometrium indicates the follicular phase; whereas, secretory endometrium indicates luteal phase. Endometrial polyps are common and usually benign. The epithelium is columnar, with only a minor degree. DDx. Obstetrics and Gynecology 29 years experience. In one study, follow-up outcomes of "gland-crowding" reports show 77% benign lesions (proliferative endometrium, secretory endometrium, endometrial polyp, etc. Of these, 33 (23%) had an outcome diagnosis of EIN (27 cases; 19%) or carcinoma (6 cases; 4%). Normal : It's benign tissue that shows estrogen effect (proliferative endometrium), cell changes that are. g. This pictorial review takes you through the hysteroscopic view of normal-looking. Pseudoneoplastic glandular response of the female genital tract, first described by Javier Arias-Stella in 1954 as atypical endometrial changes associated with the presence of chorionic tissue ( AMA Arch Pathol 1954;58:112 ) Typically found in the endometria of postabortion curettings of intrauterine or extrauterine pregnancies or with. The definition of a "normal menstrual cycle" is different for every woman. Frequently, in histological samples of EGBD, metaplastic changes occur also in the endometrial surface epithelium (Figs. Oral contraceptives (OCs) containing a low-dose, low-potency progesterone and low-dose estrogen stop proliferation of the glands during the 1st few cycles and the glands are. Compact. If conception takes place, the embryo implants into the endometrium. Keywords: endometrium, atrophic, inactive, weakly proliferative, endometrial adenocarcinoma. Doctor's Assistant: Anything else in your medical history you think the doctor should know? Metaplasia is defined as a change of one cell type to another cell type. Read More. When cancer grows in this lining, it is called. Definition and Classification. It's normal and usually means you can avoid major surgery if you have bleeding. ENDOMETRIAL. X. read more. Created for people with ongoing healthcare needs but benefits everyone. Normal : It's benign tissue that shows estrogen effect (proliferative endometrium), cell changes that are benign (ciliated metaplasia) & no precancerous or can. Normal proliferative endometrium contains glands that are regularly spaced and that lie within stroma at a gland: stroma ratio of 1 to 1. Proliferative Endometrium in Menopause: To Treat or Not to Treat? Obstet Gynecol. the expression of Bcl-2 in the proliferative phase polyps in both the glandular epithelium and stroma compared with. X. This test is also used to identify uterine infections, such as endometritis . The 2024 edition of ICD-10-CM N85. Wendy Askew answered. 0001). A weakly proliferative endometrium with focal stromal breakdown typically indicates that the endometrial lining of the uterus is not thickening as it should during the menstrual cycle. However, it can also be seen with pre-cancerous or cancerous diseases and your doctor may suggest a biopsy of the endometrium to look for more serious conditions. In this review, the criteria for adequacy and common artefacts in endometrial biopsies, as well as the interpretation of endometrial biopsies in general, are discussed,. The endometrial. What does this test result mean. comment: sections show rare strips of inactive glandular epithelium? 2 doctor answers • 2 doctors weighed in. See examples of PROLIFERATE used in a sentence. The study of endometrial carcinoma at menopause presents an interesting challenge. Pearson x2, Fisher and Wilcoxon tests were used for statistical analysis as appropriate. Endometrial polyps are overgrowths of endometrial glands that typically protrude into the uterine cavity. This book chapter provides an overview of the epidemiology, risk factors, diagnosis, staging, and treatment of endometrial cancer, as well as the latest research and guidelines. Disordered proliferation of endometrium just means that you have hormonal imbalance. Localized within the uterine wall, extends into the uterine cavity. Glands are. What do these results mean: ENDOMETRIAL BIOPSY: WEAKLY PROLIFERATIVE. This refers to: Build up of the uterine lining, as would happen in the cycle prior to ovulation (egg release) to prepare for implantation of the fertilized egg. However, it can also be seen with pre-cancerous or cancerous diseases and your doctor may suggest a biopsy of the endometrium to look for more serious conditions. The mean endometrial thickness measured on each day of the proliferation curve correlated closely with the mean estradiol levels measured on that day (coefficient 0. May be day 5-13 - if the menstruation is not included. just reading about or looking for understanding of "weakly prolif endometrium" was part of my biopsy results. It is a special type of tissue that helps hold the other parts of the organ together. Thank. Regeneration of the endometrium following repair is an estrogen-dependent process, whereby the endometrium grows from a post-menstrual depth of 0. Disclaimer: Information in questions answers, and. My endometrial biopsy says "small fragments of weakly proliferative type endometrum admixed with abundant mucus" I am currently on an OCP. Learn how we can help. To understand it fully, estrogen and progesterone are the 2 hormones that makes this proliferation in order. Definition focal overgrowth of localized benign endometrial tissue. 3,245 satisfied customers. Physician. 0000000000005054. 09–7. The endometrium becomes thicker leading up to ovulation to provide a suitable environment for a fertilized egg to grow inside the uterus. The significance of the findings is that the metaplasia may present. During menopause, the ovaries produce fewer hormones, leading to a cessation of the menstrual cycle. 2; median, 2. The presence of proliferative endometrium, adenomyosis, and cystic ovaries all are indicative of hyperestrogenic state associated with development of fibroids. The stromal cells are arranged in a compact manner. Proliferation is a noncancerous change in the endometrium. Asherman’s syndrome ( uterine adhesions) Endometrial cancer. Created for people with ongoing healthcare needs but benefits everyone. On pap tests this is associated with the classic double contoured balls of endometrial epithelium and stroma. I. 02 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. 451 views Answered >2 years ago. DIAGNOSTIC APPROACH. The endometrium from the uterine body and fundus is generally fairly uniform from one area to another. Open in a separate window. This is called the proliferative phase because the endometrium (the lining of the uterus) becomes thicker. - Negative for polyp, hyperplasia, atypia or. SCANT SUPERFICIAL FRAGMENTS OF WEAKLY PROLIFERATIVE ENDOMETRIUM, PREDOMINANTLY SURFACE EPITHELIUM. Atrophic endometrial cells, on the other hand, are smaller and more cuboidal than proliferative endometrium. Proliferative is first part of cycle, dominated by estrogen. Re: What is weakly proliferative endometrium. Main. Endometrial hyperplasia is a condition that causes abnormal uterine bleeding. TABLE 1: 2012 Summary of Physician Office Endometrial Biopsy Specimens Diagnosis Number of Cases Percentage of Cases Proliferative Endometrium 239 23. 5), with loss of distinction between the basal and functional layer; (b) proliferative type endometrial glands, somewhat tortuous, with tall. H&E stain. So during the menstrual cycle, or period, this tissue responds to. 9% of them developed endometrial cancer or hyperplasia, a four-fold greater. Infertility. SEE COMMENT. Endometriosis can reactivate after menopause, particularly if estrogen levels rise again, such as after starting hormone replacement therapy. Hyperplastic. Endometritis is inflammation of the endometrium (the inner lining of your uterus) due to infection. At the end of this stage, around the 14th day, the. It's a long-term condition that can have a significant impact on your life, but there are treatments that can help. Benign endometrial polyp, abbreviated BEP, is a common diagnosis in endometrial specimens. Read More. Definition / general. 3k views Reviewed >2 years ago. -- abundant neutrophils and blood. N85. (female) Join Date: Nov 2007. Early diagnosis and treatment of EH (with or without atypia) can prevent progression to. Definition. During the menstrual cycle, the endometrium cycles through a proliferative phase (growth phase) and secretory phase in response to hormones (estrogen and progesterone) made and released by the ovaries. 72 mm w/ polyp. does scant superficial strips of inactive endometrium seperate fragments of unremarkable squamous epithelium & mucus mean on an endometrial biops? 1 doctor answer • 2 doctors. 09–7. The functional layer thickens and then is shed during menstruation in humans and some other mammals, including apes, Old World. Doctoral Degree. EMCs. Hysteroscopy is the gold standard to evaluate the endometrial cavity. Included were 18 cases (55%) diagnosed within the first year and presumed concurrent, and an. Weakly proliferative endometrium does not denote a specific functional state but is better conceptualized as a morphologic pattern. Risk factors for developing endometrial cancer after benign sampling Factors independently associated with subsequent endometrial cancer. Ciliated cell changes (tubal metaplasia) is an early change. what does that mean? 1 doctor answer • 1 doctor weighed in What do these endometrial biopsy results mean:diagnosis: endometrium, biopsy - scant strips of inactive glandular epithelium admixed with inflamed mucus, keratin debris and blood. Proliferative endometrium(15%) and secretory endometrium (5%) were identified in the postmenopausal women which is a comparable finding to other studies that reported a proliferative endometrium. Share. Dr. Treatment also usually includes the removal of the fallopian tubes and ovaries, called a salpingo-oophorectomy. Endometrial polyps. An endometrial biopsy is generally performed in cases of 'dysfunctional uterine bleeding' - meaning, bleeding that is heavy, irregular, or otherwise. During the same period, there are concurrent changes in the endometrium, which is why the follicular phase is also known as the proliferative phase. 4) and their mean BMI was 31. Hysteroscopy is the gold standard to evaluate the endometrial cavity. Introduction. The endometrium is a complex tissue that cyclically regenerates every menstrual cycle in preparation for embryo implantation. what does that mean? 1 doctor answer • 1 doctor weighed inWhat do these endometrial biopsy results mean:diagnosis: endometrium, biopsy - scant strips of inactive glandular epithelium admixed with inflamed mucus, keratin debris and blood. . Disordered proliferative endometrium accounted for 5. read more. This pattern is sometimes seen in women with dysfunctional bleeding Progestational Agents Marked pseudo-decidualization of stroma. Proliferative endometrium describes the 'stage' of the endometrium when it was biopsied. 8% of all surgical specimens of women with PE. You might want to discuss low dose oral bcp's with your gyn or get a second opinion, as the bcp's stop all ovarian. Gurmukh Singh answered. No cancer: Depending on the time of your menstrual cycle, it is a normal finding. 0 x 3. , from endogenous sources such as obesity or from exogenous. Endometrial carcinoma is the most common invasive neoplasm of the female reproductive tract. What do these results mean: ENDOMETRIAL BIOPSY: WEAKLY PROLIFERATIVE ENDOMETRIUM WITH FOCAL STROMAL AND/OR GLANDULAR BREAKDOWN. 3–10% of endometrial biopsies are said to show histologic evidence of chronic endometritis. Disordered proliferative endometrium. •ICCR definition:-REQUIRED ELEMENTS- those which are unanimously agreed by the panel to be essential for the histological diagnosis, clinical. Pathology 51 years experience. Among those women, 278 had a proliferative endometrium, and 684 had an atrophic endometrium. Looking for help on a biospy report : weakly proliferative endometrium with progestin effect description is Fixative:Formalin NO. Read More. 1,758 satisfied customers. your doctor should check your estrogen and LH and FSH hormone levels to see if they are normal. The endometrium represents the inner glandular epithelial lining of the uterus and provides a nourishing environment for possible implantation of the blastocyst. Endometrial hyperplasia (EH) is a proliferation of endometrial glands which is typically categorized into two groups: EH without atypia (usually not neoplastic) and EH with atypia (neoplastic; also referred to as endometrial intraepithelial neoplasia [EIN]). (47). The endometrium repairs itself and it becomes thicker. Papillary Proliferation Metaplasia in Endometrium is a type of metaplasia noted in the uterine corpus. The endometrium, a tissue of continuously changing patterns and immense proliferative activity during a woman’s reproductive life, becomes atrophic after the menopause as a result of ovarian failure. The significance of the findings is that the metaplasia may present an. Results: After intervention in letrozole group, response to treatment was seen in 93% cases (including endometrial atrophy in 58. 7% cases and weakly proliferative endometriumDefinition. A: Low power view shows many morule formations in the endometrium. -- abundant neutrophils and blood. When cancer grows in this lining, it is called. The inactive endometrium was atrophic either under physiological condition or under GnRH-antagonist treatment. Changes at the lower end of the histological spectrum are referred to as “disordered proliferative endometrium” (DPE), which describes a proliferative endometrium (PE) lacking the usual regularity of gland size and spacing. benign. Before treatment, 56 subjects (60%) had an endometrial biopsy with findings classified as weakly proliferative or proliferative. . Proliferative endometrium suggests active estradiol secretion, akin to that seen in the proliferative phase of the menstrual cycle, and is not a form of EH. The physiologic changes of the endometrium during reproductive life and after menopause reflect the influence of ovarian-secreted steroid sex hormones and of their withdrawal. 2 vs 64. 2 percent) By comparison, the background prevalence of endometrial pathology in postmenopausal patients without bleeding is lower. Plasma cells were rare in inactive endometrium and noted in only 18% of unremarkable proliferative endometrium, all grade 1. focal mucinous metaplasia. A secondary goal is to exclude other intraabdominal processes (eg, diverticular disease,. The clinical significance of EH lies in the associated risk of progression to endometrioid endometrial cancer (EC) and ‘atypical’ forms of EH are regarded as premalignant lesions. 81, p < 0. 2. The aim of this review is to update current issues and provide a classification with a practical clinicopathological approach. However, adenomyosis can cause: Heavy or prolonged menstrual bleeding. Initial evaluation — The primary goal in the diagnostic evaluation of postmenopausal patients with uterine bleeding is to exclude. , 1985). 09–7. A Verified Doctor answered. 5. 0% Exogenous. Harold Fields answered. 81, p < 0. Normal : It's benign tissue that shows estrogen effect (proliferative endometrium), cell changes that are benign (ciliated metaplasia) & no precancerous or can. The endometrium is obtained for evaluation by a process called dilatation and curettage or by endometrial biopsy. Endometrial stromal tumors (ESTs) are rare mesenchymal tumors occurring primarily in the uterine corpus. What do these results mean: ENDOMETRIAL BIOPSY: WEAKLY PROLIFERATIVE. Endometrial Stromal Nodule (ESN) and Low-Grade Endometrial Stromal Sarcoma (LG-ESS) ESN is a benign, whereas LG-ESS is a malignant neoplasm of the uterus (affecting the body of the uterus more than the cervix) and extra-uterine sites [8,9]. ( I have had 5 endometrium biopsies over past 4 years and one D&C 6 years ago) • 01-2021 Endo Biopsy Diagnosis: Pre-hyperplasia, Disordered proliferative endometrium without atypia. An introduction to the endometrium is found in the endometrium article. However, proliferative patterns observed in anovulatory premenopausal women or in postmenopausal women, if not corrected, signify an excess of estrogen that may place women at higher risk. The mean BMI of the cohort was 34. Endometrium at menopause is inactive and free of cyclical changes that are characteristics of the reproductive age. 11. Code History. My pathology report final diagnosis are as follows: Endometrium biopsy: blood and weakly proliferative phase endometrium with glandular and stromal breakdown. Microscopic findings. Doctor's Assistant: When was your last pap smear? Have you ever had an irregular pap? My pap was good clinical history is abnormal uterine bleeding. Discussion 3. stroma. Glands/cells identical to proliferative endometrium Abundant stroma Gland:Stroma ratio often 1:1, if becomes >2:1, then consider hyperplasia (see endometrial tumor notes) Often coinciding breakdown Endometrial glands and stroma outside of their usual endometrial cavity location→cause dysmenorrhea and/or menorrhagia Adenomyosis Atrophic endometrium is a normal finding in prepubertal, postmenopausal, and some perimenopausal women. 2 mm thick (mean, 2. read more. I'm 51, no period 8 months, spotting almost every day for year. Pediatrics 35 years experience. 2; median, 2. 02 - other international versions of ICD-10 N85. 5 ±17. The uterus is lined with a special tissue called the endometrium. ". The immunohistochemical staining pattern for CD138 with appr. Dr. Occasionally in the latter situation, when the proliferative phase is prolonged, there may be sufficient residual oestrogen secretion toWhat does weakly proliferative mean? Atrophic/weakly proliferative endometria were defined by the following criteria: (a) a shallow endometrium 2. Most women (90%) with endometrial cancer develop symptomatic vaginal bleeding or discharge, and this is often what prompts them to seek gynecologic care. Created for people with ongoing healthcare needs but benefits everyone. However, in some instances, they cause pain, irregular bleeding, or infertility. No malignancy was recognized. The belief that stromal cell proliferations in the endometrium are by definition neoplastic was first challenged by Stewart et al. A Verified Doctor answered. The endometrium is the inner epithelial layer, along with its mucous membrane, of the mammalian uterus. The immunohistochemical staining pattern for CD138 with appr. Family Medicine 49 years experience. Hormonal or irritative stimuli are the main inducing factors of EMCs, although some metaplasias have a mutational origin. The risk. Methods. Fewer than 2% of cases of endometrial hyperplasia without cytological atypia progress to endometrial carcinoma, compared with 23% of cases of endometrial hyperplasia with cytological atypia that progress to carcinoma (atypical hyperplasia; Kurman et al. Stroma is the connective tissue just below the surface of an organ. What. ), 19% premalignant lesions, and. It is a normal finding in women of reproductive age. It is also known as atrophy of the endometrium and endometrial atrophy . Read More. Disordered proliferative endometrium with glandular and stromal breakdown. Postmenopausal bleeding. Adenofibroma is a mixed tumor of the endometrium (and rarely also of the cervix) consisting of a benign epithelial and a benign mesenchymal component, both of which are integral components of the neoplasm. At the start of the menstrual cycle, the ovaries secrete the estrogen hormone, triggering the endometrium to enter a proliferative phase, during. This code is applicable to female patients only. The lining of the uterus (endometrium) becomes unusually thick because of having too many cells (hyperplasia). Pseudoneoplastic glandular response of the female genital tract, first described by Javier Arias-Stella in 1954 as atypical endometrial changes associated with the presence of chorionic tissue ( AMA Arch Pathol 1954;58:112 ) Typically found in the endometria of postabortion curettings of intrauterine or extrauterine pregnancies or with. Hence, it is also known as Metaplastic Changes in Endometrial Glands. For example, the endometrium in most term foetuses and neonates is only weakly proliferative, despite prolonged exposure to very high concentrations of unbound estrogens and progesterone in utero. endometrium, biopsy: - consistent with menstrual endometrium: -- stripped weakly proliferative endometrial glands. Endometrial hyperplasia is caused by an imbalance in the hormones involved in the normal menstrual cycle. Best would be to contact the pathologist who wrote the report. Women with a proliferative endometrium were younger (61. Learn how we can help. 0001) and had a higher body mass index (33. the mean age, weight, FSH and oestradiol. read moreEndometrial Hyperplasia; An Update on Human Papillomavirus Vaccination in the United States; Effect of Second-Stage Pushing Timing on Postpartum Pelvic Floor Morbidity: A Randomized Controlled Trial; Permanent Compared With Absorbable Suture in Apical Prolapse Surgery: A Systematic Review and Meta-analysisUterine corpus cancer is the most prevalent gynecologic malignancy in American women with over 60,000 new cases expected during the next year and accounting for nearly 11,000 deaths. 8 is applicable to female patients. -. The uterus is a muscular, pear-shaped, hollow organ that forms an important part of the. Some fragments may represent. Normal proliferative endometrium contains glands that are regularly spaced and that lie within stroma at a gland: stroma ratio of 1 to 1. Norm S. This condition is detected through endometrial biopsy. The prevalence of endometriosis in reproductive-aged women is 2% to 10%, while in those who have been through menopause, the prevalence is an estimated 2. Very heavy periods. received endo biopsy result of secretory, focally inactive endometrium, neg for hyperplasia and malignancy. Weakly proliferative endometrium Normal proliferative endometrium Disordered proliferative Endometrial hyperplasia Asynchronously developed endometrium. This highly regenerative capacity is likely driven by stem/progenitor cell populations that reside in the basalis. -- balls of condensed endometrial stroma. 1 To fulfil this latter role, the endometrium is unique in that it undergoes cyclical epithelial and stromal morphogenesis during the reproductive years. 2; median, 2. The endometrium is normal proliferative phase in which buds of small morules were scattered (Figure 1C). - Negative for. The functional layer thickens and then is shed during menstruation in humans and some other mammals, including apes, Old World. Proliferative is first part of cycle, dominated by estrogen. It is further classified. The degree of proliferation can vary in proportion to the estrogenic stimulus. Objective In the last two decades, many reports demonstrated the unreliability of endometrial biopsy pathology showing an AH (atypical hyperplasia) to exclude a synchronous EEC (endometrioid endometrial carcinoma), with an underestimation of EEC in up to 50% of women. In this study we correlate the # of plasma cells by H&E to the # of plasma cells by CD138 IHC in endometrial biopsies. In the past, the terms “adenomatous hyperplasia” and “atypical hyperplasia” were used to denote proliferative lesions of the endometrium with varying degrees of architectural complexity and cytologic atypia [15, 32, 37, 70, 93]. 9 and 12. Doctor's Assistant: Anything else in your medical history you think the doctor should know?Metaplasia is defined as a change of one cell type to another cell type. Endometrial hyperplasia is a condition that causes abnormal uterine bleeding. Fibroids (benign uterine muscle growths) and polyps (endometrial masses) often cause no symptoms. Read More. Metaplasia is defined as a change of one cell type to another cell type. Biopsy results may show cell changes linked to hormone levels, or abnormal tissues, such as fibroids or polyps. However, certain conditions can develop if the. g. The endometrium, a tissue of continuously changing patterns and. The histologic effect depends on the hormone, the potency, dosage, and the host receptor status. These symptoms can be uncomfortable and disruptive. The study provides. The basic effect of estrogens on the endometrium is to induce proliferation of the endometrial glands and stroma, including vascular endothelium. endometrium, biopsy: - consistent with menstrual phase endometrium: -- weakly proliferative endometrial glands with neutrophils and apoptosis. A member asked:. 3% had proliferative pattern (disorder type) tissue; 0. DDx. 6 percent) Fibroid (6. Only in postmenopaus: The endometrium is the lining of the uterus, and it 'proliferates' during the 1st 1/2 of the menstrual cycle under the influence of the estrogen that. [10]: (1) constant appearance of basalis throughout the menstrual cycle, (2) glands of the basalis appear weakly proliferative, (3) basalis cells lack secretory features and the stroma is spindled. 5% of women with abnormal uterine bleeding had proliferative or secretory endometrium. What do the results of my endometrial biopsy mean? Here are some words and phrases you might see on your biopsy results: Proliferative endometrium; Atrophic endometrium ; Hyperplasia; Carcinoma; If you see either of the first two phrases, your results are normal. Blood. Even if the 50% (1:1) cutoff is the most practical from a diagnostic and clinical perspective, what. This definition comprises various types of hormonally induced metaplastic changes in the endometrium observed both in benign and premalignant or malignant conditions [9,10,11]. Over ten years if not treated, this can raise the risk of uterine malignancy. 2 percent) Hyperplasia without atypia (2 percent) Hyperplasia with atypia (0. 8 may differ. About 3. Endometrium at menopause is inactive and free of cyclical changes that are characteristics of the reproductive age. - Negative for polyp, hyperplasia, atypia or. Chronic plasmacytic endometritis (CPE) is an infectious or reactive process with multiple etiologies. Hormone replacement therapy with estrogen alone may result in continuous endometrial proliferation, hyperplasia, and neoplasia. Epub 2023 Jan 4. this is a description of the uterine lining in response to estrogen. For example, the endometrium in most term foetuses and neonates is only weakly proliferative, despite prolonged exposure to very high concentrations of unbound estrogens and progesterone in utero. I'm sure your physician is monitoring your endometrial lining via biopsy or D&C to make sure that you aren't at increased risk of endometrial hyperplasia or pre-cancer of the endometrium. Hysteroscopy can identify malignant or benign pathology with approximately 20% false-positive results. 2 Proliferative Endometrium4,572 satisfied customers. Recognition as an Endometrial Stromal Neoplasm (Biopsy/Curettage Specimen) The first clue that a biopsy/curettage specimen harbors an endometrial stromal neoplasm is the finding of multiple. In addition, the term “carcinoma in situ” was proposed to describe small lesions, with or. Methods. 14. Cardiovascular surgeon. 3%) 'gland crowding' cases were identified, in which 69% (143/206) had follow-up sampling. Read More. Contact your doctor if you experience: Menstrual bleeding that is heavier or longer-lasting than usual. Characteristics. when they faced with a series of two endometrial biopsies and a subsequent hysterectomy specimen of a young woman with menorrhagia. 3k views Reviewed >2 years ago. I. The specimen is received. Glands. Endometrial metaplasia can be associated with hyperestrogenism, inflammation, repeated irritation or endometrial polyps. In contrast, the non-neoplastic component of 43 of the 50 endometrial adenocarcinomas examined was of the active form; four specimens were of the pure and 39 of the mixed. Lindemann. Endometrium in proliferative phase, secretory phase, endometrial polyps, and disordered proliferative endometrium were studied for the presence of plasma cells. SEE COMMENT. Ultrasound Results mild endometrial thickening 7-8 mm. isnt the first part contradictory of each other or is everything normal?" Answered by Dr. Menstrual bleeding between periods. Disordered proliferative endometrium (DPE) and hyperplasia without atypia. Endometriosis often involves the pelvic tissue. We performed p16 immunostaining on 35 normal endometrial specimens and 32 EPs, six of which were associated with tamoxifen therapy. 11,672. Weakly proliferative endometrium is a normal finding in some women, but it can also be a sign of cancer or other problems. common. Cardiovascular surgeon. Read More. Endometriosis often involves the pelvic tissue and can envelop the ovaries and fallopian tubes. Common reasons for these procedures include: Abnormal (dysfunctional) uterine bleeding.